Lil' Miss is very efficient in running her crime syndicate. By the time her bar is visited by Cinder Fall, the gangster has amassed several followers and has them all wear a spider tattoo somewhere on their bodies. Lil' Miss seems to have gained respect from her subordinate that she has bodyguards to protect her from intruders.
From her own words on her origins and her fear of Spiders, its possible that Lil Miss Malachite was not the original leader or founder of the group and had instead wrestled control of it sometime during her youth.
Lil' Miss is Melanie and Miltia's mother, as revealed in the Volume 6 commentary.
When Lil' Miss is approached by the Fall Maiden in "Uncovered", she permits Cinder to have a talk only after the latter offers Lien and does not like the tone of demeanor by which she is addressed at first. She manages to intimidate the Maiden when she reveals that every customer at the bar works for her. Lil' Miss promises Cinder that her gang will find her targets, but it is later revealed that she intentionally withheld the location of Ruby Rose and her allies because she wants to know who in Mistral is searching for the Maiden due to wanting to double her profit by selling Cinder's location to perhaps another client searching for her.
In "The Coming Storm", it was shown that she knew who Cinder is and doesn't mind having her as a customer. During Cinder and Neo's fight, she asks her and Neo to take their fight outside since she doesn't want her tavern to be destroyed by them.
Lil' Miss Malachite is shown to have a business relationship with Neopolitan, as seen where she took her up as a client for information and agreed to give her Cinder Fall's location and lured her to her bar and allow Neo to confront her directly.
Although their exact relationship is unknown, its likely that Neo has some strong ties or connections with Lil Miss or her organization as she prioritized Neo instead of selling off Cinder's location to anyone else despite their being numerous others who where pursuing her.
As seen during his meeting with Salem and his other acquaintances, Hazel had also done some business and had a meeting with Lil Miss Malachite and her organization in order to acquire information from her. This was stated where after Cinder made her own inquiry about Ruby and her Group's location or where they were heading, Lil Miss remembered that Hazel had also come to them to buy the same information from her.