User blog comment:Mathias Custos/Fandom unite/@comment-25555436-20150729010014/@comment-25555436-20150729135620

It doesn't matter. Just kidding, I just wanted to say that.

But seriously, when refering to something with no identifiable gender, I still think it's best to use It. It could be a man, a woman, both or even none. Probably even something else. Until you know as what gender they identify, or if they can even be identified with a gender, you could use it. If they find it offensive, even better; they will quickly make sure to correct you and state their gender, making future conversation easier.

Now, if they have something like Dissociative Personality Disorded They may be a perfect pronoun.

With Penny is different. Her appearance+voice+name=Female. You can easily, inmediately see Penny as a girl, even if you don't consider her human, and should refer to her with female pronouns instead. As such, it's different.