Board Thread:Off Topic/@comment-25898433-20141220121855/@comment-25555436-20141223235418

Well, depends. Do it wrong, makes no sense at all and/or feels like a wasted oportunity. However, it can be done right if you know what you're doing, and know what you're using.

You need to know about both universes, how they work, and think of how the characters could interact, depending on the kind of plot you want. For a crack, imagine how Wolverine would react if he was sent to Equestria (that is, MLP:FiM).

Examples I've found of it done...well enough at least...I know 2:

-Sonic/Megaman comic that I always forget it's name.

-Carnival Phantasm, which is a hilarious cross of Fate/Stay Night and Tsukihime/Melty Blood. Must Watch.